FMC Corporation announced that the Mexican Federal Court of Administrative Justice (Tribunal Federal de Justicia Administrativa, Sala Especializada en Materia de Propiedad Intelectual) granted an injunction in an action discussing patent infringement related to chlorantraniliprole (chlorantraniliprole, Rynaxypyr) in that country. At the other pole of the action is Rainbow Agro Sciences. The official version can be read in the link at the end of this article.
According to company information, chlorantraniliprole is "FMC's main insecticidal ingredient", marketed under the brand name Rynaxypyr active.
Additionally, the injunction orders the Federal Committee for Protection against Health Risks to prohibit the import and export of Rainbow's technical chlorantraniliprole in Mexico and denies Rainbow any registration for products formulated containing chlorantraniliprole.
"We are pleased with the Court's decision, which reflects its understanding of the urgency of this matter and the importance of using genuine, registered crop protection technologies on farms in Mexico," said Michael Reilly, Executive Vice President, General Counsel and Secretary from FMC.
"The principles decided by the Court are significant for future infringement actions and reinforce FMC's confidence in protecting and enforcing its patents around the world. Our intellectual property rights are an essential tool for driving innovation and continued significant investment in new crop protection solutions.”
Chlorantraniliprole is an insecticide belonging to the chemical class of anthranilic diamides. It is intended to control lepidoptera, coleoptera and some dipteran pests. It is an insecticide with an active residual effect on larvae, as well as on some adults, both through ingestion and contact as routes of entry. According to the literature, ingestion is the most effective method of entry and typically requires a lower dose for response.
The product was developed by DuPont in 2007. And acquired by FMC due to determinations by antitrust bodies when DuPont and Dow created Corteva (see here). Its formulations include WG (water-dispersible granular) and SC (suspension concentrate).
The molecule received several commercial names, such as Rynaxypyr (for the technical material) and Altacor, Coragen, Prevathon, Dermacor X-100 and Ferterra for the formulations. The molecule's development code at DuPont was DPX-E2Y45.
According to the scientific literature, the mode of action of chlorantraniliprole (MOA) involves the unregulated activation of ryanodine receptor channels, leading to the depletion of internal calcium storage, which impairs the regulation of muscle contraction. Insects exposed to chlorantraniliprole exhibit general lethargy and muscular paralysis followed by death.
Chlorantraniliprole and other compounds belonging to the anthranilic diamide class of insecticides have been shown to be highly potent activators of insect ryanodine receptors. In physiological studies carried out with neurons isolated from the American cockroach (American periplanet), chlorantraniliprole stimulates the release of calcium stores via selective activation of the ryanodine receptor.
The process of insect muscle contraction involves the modulation of two distinct calcium channels, voltage-gated calcium channels that regulate external calcium entry and ryanodine receptor channels that regulate the release of internal calcium stores from the sarcoplasmic reticulum. Under normal physiological conditions, input from the nervous system activates voltage-gated calcium channels, leading to an increase in intracellular calcium. This increase triggers the activation of ryanodine receptor channels located in the sarcoplasmic reticulum, resulting in the release of stored reserves of internal calcium and initiating a muscle contraction. Following this muscle contraction, ryanodine receptor channels close, allowing calcium stores to be replenished in preparation for the next stimulated contraction.
Study results indicate that "chlorantraniliprole exhibits excellent differential selectivity for insect ryanodine receptors relative to mammalian ryanodine receptors."
The CAS registration number for chlorantraniliprole is 500008-45-7. The product is classified in Irac group 28.
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